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The non-confidential portion of EPA’s Toxic Substances Control Act Chemical Substance Inventory (TSCA Inventory) is updated approximately every six months. It can be searched in multiple ways. This page provides ways to download the non-confidential Inventory and offers help in using these downloaded files. The February 2021 update is available below. The Inventory contains 86,557 chemicals of which 41,864 are active.

On this page:

Download the non-confidential TSCA Inventory

EPA provides a Microsoft Access version and a generic comma-delimited 'CSV' text version of the non-confidential TSCA Inventory for users to download. If you don't have Microsoft Access, use the CSV file. Both files are compressed '.zip' files. The .zip files contain the actual data files. See generic information about zip files.

On February 9, 2021, EPA posted an updated version of the TSCA Inventory files originally posted on February 3, 2021. The unique identifier data in these newer Inventory files was updated to align with data in EPA’s confidential business information review and determination posted on February 8, 2021.​

MS Access Non-CBI TSCA Inventory (ZIP) (zip) (Last created: 02/2021)

CSV Non-CBI TSCA Inventory (ZIP) (zip) (Last created: 02/2021)

The Microsoft Access file contains two tables:

  • TSCAINV_022021
    • Contains non-confidential chemical substance listings on the TSCA Inventory, as identified by Chemical Abstract Service (CAS) Registry Number and Chemical Abstracts (CA) Index Name.
  • PMNACC_022021
    • Contains non-confidential data for the confidential chemical substance listings, as identified by EPA accession number and generic chemical name.

The Comma Separated Value (CSV) text version contains two *.CSV tables:

  • TSCAINV_022021.csv
    • Contains non-confidential chemical substance listings on the TSCA Inventory, as identified by CAS Registry Number and CA Index Name.
  • PMNACC_022021.csv
    • Contains non-confidential data for the confidential chemical substance listings, as identified by EPA accession number and generic chemical name.

For all files: users may need to adjust formatting, including column widths.

Learn how the data is formatted to help you search

You can perform basic searches or sort the information in different ways.

  • Use a basic 'find' search function and type in a part of a chemical name or CAS Registry Number.
  • You may be able to do different or more complex searches or sorts -- see your own software help system or your local computer support personnel for additional instructions.

The following data fields are provided for each non-confidential chemical substance:

Field
ID
Data Data Must Be Present? Multiple Values Possible?
ACTIVITY Commercial Activity Status ** Y N
CASRN Chemical Abstracts Service (CAS) Registry Number Y N
casregno CAS Registry Number without '-' [dashes] Y N
ChemName Preferred Chemical Abstracts (CA) Index Name * Y N
DEF Chemical Substance Definition * N N
EXP Expiration Date N N
FLAG EPA TSCA Regulatory Flag ** N Y ***
ID Record ID Number Y N
UID Unique Identifier N N
UVCB UVCB Flag N N

* These data can be greater than 256 characters in length.
** Multiple values are separated by a semicolon and space.
*** Information on EPA TSCA regulatory flags is provided below.

The following non-confidential data fields are provided for each confidential chemical substance:

Field
ID
Data Data Must Be Present? Multiple Values Possible?
ACCNO EPA Accession Number Y N
ACTIVITY Commercial Activity Status ** Y N
EXP Expiration Date N N
FLAG EPA TSCA Regulatory Flag ** N Y ***
GenericName Generic Name * Y N
ID Record ID Number Y N
PMNNO PMN Number/Form Number Y N
UID Unique Identifier N N
* These data can be greater than 256 characters in length.
** Multiple values are separated by a semicolon and space.
*** Information on EPA TSCA regulatory flags is provided below.

NOTE: A 'Chemical Substance Definition' in the DF field provides important identification information for certain Class 2 substances having 'Preferred CA Index Names' that are not specific or complete enough to permit unambiguous identification of the substance or the category to which it belongs.

The presence of 'UVCB' in the UV field indicates the substance is a Class 2 substance within the UVCB group, i.e., those with “unknown” or “variable composition,” “complex reaction products” and “biological materials.” These substances have no definite molecular formula representation and either partial or no structural diagrams.

The ASCII character set is used, with Field IDs in upper case and the data themselves in upper and lower case. Special characters are handled using the following conventions:

  • Greek letters - name of letter within periods, e.g., the alpha is represented as '.alpha.'
  • The degree sign in temperatures is represented as '.degree.'

All fields pertaining to a particular chemical substance are grouped together into a single substance record. For ease of use with data management software, records are separated from each other by a carriage return and a newline. The last (eighth) field ends with a carriage return and a newline instead of a tab.

All field identifiers are present in a record even if some fields have no data. If there are no data, the field ID (with colon) is immediately followed by a tab unless it is the last field of the record, in which case the field ID (with colon) is immediately followed by a carriage return and newline. As indicated above, the SN and FL fields can have multiple values of data. In such cases, each value is separated from the one following by a semicolon followed by a space.

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Meaning of EPA regulatory flags

Special flags are used throughout the TSCA Inventory to identify those substances on the Inventory that are the subject of an EPA rule or order promulgated under TSCA, as well as to indicate types of full or partial exemptions from TSCA reporting requirements.

The following flags are used:

  • 5E - indicates a substance that is the subject of a TSCA section 5(e) order.
  • 5F - indicates a substance that is the subject of a TSCA section 5(f) rule.
  • 12C - indicates a substance that is prohibited to be exported from the Unites States under TSCA section 12(c).
  • FRI - indicates a polymeric substance containing no free-radical initiator in its Inventory name but is considered to cover the designated polymer made with any free-radical initiator regardless of the amount used.
  • PE1 - indicates a polymer that has a number-average molecular weight of greater than or equal to 1,000 daltons and less than 10,000 daltons and that is exempt under the 1995 polymer exemption rule. The polymer's oligomer content must be less than 10 percent by weight below 500 daltons and less than 25 percent by weight below 1,000 daltons.
  • PE2 - indicates a polymer that has a number-average molecular weight of greater than or equal to 10,000 daltons and that is exempt under the 1995 polymer exemption rule. The polymer's oligomer content must be less than 2 percent by weight below 500 daltons and less than 5 percent by weight below 1,000 daltons.
  • PE3 - indicates a polymer that is a polyester and that is exempt under the 1995 polymer exemption rule. The polyester is made only from monomers and reactants included in a specified list that comprises one of the eligibility criteria for the 1995 polymer exemption rule.
  • PMN - indicates a commenced PMN substance.
  • R - indicates a substance that is the subject of a proposed or final TSCA section 6 risk management rule.
  • S - indicates a substance that is identified in a final Significant New Use Rule.
  • SP - indicates a substance that is identified in a proposed Significant New Use Rule.
  • T - indicates a substance that is the subject of a final TSCA section 4 test rule or order.
  • TP - indicates a substance that is the subject of a proposed TSCA section 4 test rule or order.
  • XU - indicates a substance exempt from reporting under the Chemical Data Reporting Rule, (40 CFR 711).
  • Y1 - indicates a polymer that has a number-average molecular weight greater than 1,000 and that was exempt under the 1984 polymer exemption rule.
  • Y2 - indicates a polymer that is a polyester and that was exempt under the 1984 polymer exemption rule. The polyester is made only from reactants included in a specified list of low-concern reactants that comprises one of the eligibility criteria for the 1984 polymer exemption rule.

Alternate ways to access the non-confidential TSCA Inventory

In addition to downloading a Microsoft Access version and a generic comma-delimited 'CSV' text version, the non-confidential TSCA Inventory can be searched in multiple ways:

Use EPA's Substance Registry Services (SRS) to search the non-confidential TSCA Inventory

  • Go to Substance Registry Services (link opens in a new tab)
  • Select the “search by list' option
  • Type 'TSCA Inventory' in the List Name field
  • Click the 'filter' button and select 'TSCA Inventory – TSCA Inv' from the drop-down list

Look at other sources of EPA’s non-confidential TSCA Inventory data such as:

  • Government Printing Office (GPO) website no longer provides paper copies of the original 1985 TSCA Inventory publication or the 1990 Supplement; however, it can provide expert assistance in finding and using related U.S. government information.
  • Several commercial services provide searches for the non-confidential TSCA Inventory for a fee. None of these is connected to or has a specific endorsement from EPA.

The CDR® Dementia Staging Instrument in one aspect is a 5-point scale used to characterize six domains of cognitive and functional performance applicable to Alzheimer disease and related dementias: Memory, Orientation, Judgment & Problem Solving, Community Affairs, Home & Hobbies, and Personal Care. The necessary information to make each rating is obtained through a semi-structured interview of the patient and a reliable informant or collateral source (e.g., family member) referred to as the CDR® Assessment Protocol.

The provided 'Full' and 'Refresher' training on this site is technically referred to as the Brief Training & Reliability Protocol (BTRP) as it is a subset of the complete CDR® Training that takes place in-person at the Knight ADRC.

The CDR® Scoring Table provides descriptive anchors that guide the clinician in making appropriate ratings based on interview data and clinical judgment. In addition to ratings for each domain, an overall Global CDR® Score may be calculated through the use of an CDR® Scoring Algorithm. This score is useful for characterizing and tracking a patient's level of impairment/dementia:

0 = Normal

0.5 = Very Mild Dementia

1 = Mild Dementia

2 = Moderate Dementia

3 = Severe Dementia


A sample CDR® Scoring Table is available by clicking HERE.

A list of the languages that the CDR® Assessment Protocol has been translated into can be viewed HERE. Once permission has been secured to use the CDR via the Copyright/Licensing process, you will be able to download the listed translations and associated translation certificates.

The CDR® Assessment Protocol, CDR® Scoring Table, CDR® Scoring Algorithm and this training site were developed, in large part, through funding support from the following National Institute on Aging grants:

  • Alzheimer's Disease Center Grant (AG05681)
  • Healthy Aging & Senile Dementia (AG03991)
  • Alzheimer's Disease Cooperative Study (AG10483)

A brief list of literature related to the CDR® Dementia Staging Instrument can be found at the links below.

Interobserver Disagreements on Clinical Dementia Rating Assessment: Interpretation and Implications for Training. Rochelle E. Tractenberg, Kimberly Schafer, John C. Morris. Alzheimer Disease and Associated Disorders 2001; 15: 155-161. Abstract Link

Morris JC. The Clinical Dementia Rating (CDR): Current version and scoring rules. Neurology 1993; 43:2412-2414. Abstract Link

Hughes CP, Berg L, Danziger WL, Coben, LA, Martin, RL. A new clinical scale for the staging of dementia. Br J Psychiatry 1982; 140:566-572. Abstract Link

Berg L. Clinical Dementia Rating (CDR). Psychopharmacol Bull 1988; 24:637-639. Abstract Link

Morris JC, Berg L, Coben LA, Rubin EH, Deuel R, Wittenborn R,et.al Clinical Dementia Rating. In Treating 'Alzheimer's and other Dementias'. M. Bergener and S. Finkel (eds) 1995, 338-346. Morris JC, Ernesto C, Schafer K, et. al. Clinical Dementia Rating training and reliability in multicenter studies: The Alzheimer's Disease Cooperative Study experience. Neurology 1997; 48:1508-1510. Abstract Link

Rockwood K,Strang D, MacKnight C, et. al. Interrater reliability of the Clinical Dementia Rating in a multicenter trial. JAGS 2000; 48:558-559. Abstract Link

Morris JC, McKeel DW Jr, Fulling K, Torack RM, Berg L. Validation of clinical diagnostic criteria for Alzheimer's disease. Ann Neurol 1988; 24:17-22. Abstract Link

Burke WJ, Miller JP, Rubin EH, et. al. Reliability of the Washington University Clinical Dementia Rating. Arch Neurol 1988; 45:31-32. Abstract Link

Berg L. Clinical Dementia Rating [correspondence]. Br J Psychiatry 1984; 145:339. Abstract Link

Berg L, Miller JP, Storandt M, et. al. Mild senile dementia of the Alzheimer type: 2. Longitudinal assessment. Ann Neurol 1988; 23:477-484. Abstract Link

McCulla MM, Coats M, Van Fleet N, Duchek J, Grant E, Morris JC. Reliability of clinical nurse specialists in the staging of dementia. Arch Neurol 1989; 46:1210-1211. Abstract Link

Use all information available and make the best judgment. Score each category (M, O, JPS, CA, HH, PC) as independently as possible. Mark in only one box, for each category, rating impairment as decline from the person’s usual level due to cognitive loss alone, not impairment due to other factors, such as physical handicap or depression. Occasionally the evidence is ambiguous and the clinician’s best judgment is that a category could be rated in either one of two adjacent boxes, such as mild (1) or moderate (2) impairment. In that situation the standard procedure is to check the box of greater impairment.

Aphasia is taken into account by assessing both language and non-language function in each cognitive category. If aphasia is present to a greater degree than the general dementia, the subject is rated according to the general dementia. Supply evidence of non-language cognitive function.

The Global CDR® Score is derived from the scores in each of the six categories ('box scores') as follows. Memory (M) is considered the primary category and all others are secondary. CDR = M if at least three secondary categories are given the same score as memory. Whenever three or more secondary categories are given a score greater or less than the memory score, CDR = score of majority of secondary categories on whichever side of M has the greater number of secondary categories. When three secondary categories are scored on one side of M and two secondary categories are scored on the other side of M, CDR=M.

When M = 0.5, CDR = 1 if at least three of the other categories are scored one or greater. If M = 0.5, CDR cannot be 0; it can only be 0.5 or 1. If M = 0, CDR = 0 unless there is impairment (0.5 or greater) in two or more secondary categories, in which case CDR = 0.5.

Although applicable to most Alzheimer's disease situations, these rules do not cover all possible scoring combinations. Unusual circumstances occur occasionally in Alzheimer's disease and may be expected in non-Alzheimer dementia as well are scored as follows:

  • With ties in the secondary categories on one side of M, choose the tied scores closest to M for CDR (e.g., M and another secondary category = 3, two secondary categories = 2, and two secondary categories = 1; CDR = 2).
  • When only one or two secondary categories are given the same score as M, CDR = M as long as no more than two secondary categories are on either side of M.
  • When M = 1 or greater, CDR cannot be 0; in this circumstance, CDR = 0.5 when the majority of secondary categories are 0.

Morris, J.C. (1993). The clinical dementia rating (CDR): Current version and scoring rules. Neurology, 43(11), 2412-2414.

To view these rules as a PDF, click the image below.

Copyright, Licensing & Translations

The Charles F. and Joanne Knight Alzheimer's Disease Research Center (Knight ADRC) holds the United States Copyright for the Clinical Dementia Rating (CDR®) Dementia Staging Instrument and associated training materials. An important part of the Knight ADRC's educational mission is to ensure that the CDR® Dementia Staging Instrument is widely and readily available for use by professionals in clinical and research settings. Protecting the integrity of the instrument and ensuring appropriate utilization are equally important priorities.
The CDR® Scoring Table and rules were published in the journal NEUROLOGY, 1993; 43:2412-2414 (author Morris, JC). Reprinting of this table in a publication requires permission from the publisher - Lippincott, Wilkins & Williams.

A list of the languages that the CDR® Assessment Protocol has been translated into can be viewed HERE. Once permission has been secured to use the CDR via the Copyright/Licensing process below, you will be able to download the listed translations and associated translation certificates.

If you would like to license the CDR® Dementia Staging Instrument (non-profit and for-profit), please visit https://otm.wustl.edu/washu-innovations/tools/. Select the response that applies to your intended use of the CDR® Dementia Staging Instrument.


Training


Prospective users of the CDR® Dementia Staging Instrument should be trained to administer the semi-structured interview and use the Scoring Table in a valid, reliable manner. We prefer to provide such training through live, in-person sessions either at our offices or at pre-arranged remote events. Such live training is often not possible, however. The CDR® On-line Training System was developed with two purposes in mind: (1) as a supplement to in-person training and (2) as a stand-alone training option for individuals and groups that cannot participate in an in-person session. In-person training is important to ensure valid administration, whereas the on-line system helps to ensure reliability in scoring.

Public Training (Free Access)

There is no a charge option available to individual trainees wishing to be trained online. English and Spanish subtitles are provided for this free training option. See Private Training below concerning the availability of other subtitle languages. The Washington University Knight ADRC reserves the right to bar access to prospective trainees who do not provide a bona fide reason for receiving training. Minimal technical support is provided. Access to an expert for training questions is not provided. It is expected that trainees who take the online training are already familiar with the CDR® Dementia Staging Instrument. A certificate is issued for those who pass the training. A limited set of remedial modules is provided for trainees that fail their initial training modules. The initial set of 9 training modules generally takes between 8-9 hours (depending upon familiarity with the CDR® Dementia Staging Instrument).

Private Training (Group or Corporate Access, Fee Based)


Group or corporate users of the training system should contact Ronald Hawley concerning training access options and applicable fees.

As of 5/12/2017, the fee-based training option provides subtitles for all training videos in Arabic, Bulgarian, Chinese (Simplified & Traditional), Dutch, English, English UK, French, German, Hebrew, Italian, Japanese, Korean, Polish, Portuguese (Brazil), Portuguese (Portugal), Russian, Spanish (International), Spanish (Latin America), Croatian, Danish, Hungarian, Turkish, Lithuanian, Finnish, Czech and Swedish. This option also provides access, if needed, to an expert at the Knight ADRC should concerns or questions arise during training. Additionally, technical support is provided. If a streaming problem cannot be solved, a set of training DVDs will be sent via FedEx at no additional charge. A limited set of remedial modules is provided for trainees that fail their initial training modules. Finally, not only will a trainee receive a certificate upon successful completion of the training, individuals within the trial's organizing institution can also be designated to receive the same certificate--eliminating the need for a trainee to forward his/her certificate.

Confidentiality Protection


The CDR® On-line Training System utilizes video segments of real patient interviews. All interview participants provided informed consent for their images to be shown for appropriate educational purposes. Apart from the visual appearance of each interviewee, there is no other identifying information in these interview segments. Nevertheless, we ask that approved trainees (1) respect the confidentiality of those they observe and (2) refrain from discussing interview content with others. Browsers of the CDR® On-line Training System may view certain video segments but with the faces of interviewees blocked out.

You can click HERE to use the online CDR® Scoring Algorithm. The linked page allows the user to input CDR® Box Scores and submit them to a SAS computer program which returns the Global CDR® Score.

Online Certification Training


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Free training in the CDR® Dementia Staging Instrument is provided by clicking HERE. Once your application has been submitted, you'll immediately be able to begin training. Minimal technical support is provided. Access to an expert or training questions is not provided. It is expected that trainees who take the online training are already familiar with the CDR® Dementia Staging Instrument. A certificate is issued for those who pass the training. A limited set of remedial modules is provided for trainees that fail their initial training modules. The initial set of 9 training modules generally takes between 8-9 hours (depending upon familiarity with the CDR® Dementia Staging Instrument). Free training includes English and Spanish subtitles.

Group or corporate users of the training system should contact Ronald Hawley concerning training access options and applicable fees. As of 5/12/2017, the fee-based training option provides subtitles for all training videos in Arabic, Bulgarian, Chinese (Simplified & Traditional), Dutch, English, English UK, French, German, Hebrew, Italian, Japanese, Korean, Polish, Portuguese (Brazil), Portuguese (Portugal), Russian, Spanish (International), Spanish (Latin America), Croatian, Danish, Hungarian, Turkish, Lithuanian, Finnish, Czech and Swedish. This option also provides access, if needed, to an expert at the Knight ADRC should concerns or questions arise during training. Additionally, technical support is provided.

Sample CDR Training


Browsing the CDR® Dementia Staging Instrument allows those not interested in formal training to view three sample training videos. These videos have been altered to remove the individuals' faces to protect their identity. If after viewing the samples videos you wish to take the formal training, a link will be provided to do so. Begin by clicking HERE.


Streaming Requirements


Click HERE to view our streaming requirements page.


Lost your place during training?


If you've lost your place during training, click HERE to submit a request for a link to resume.

Private training access


Group or corporate interested in accessing/setting up Private training should contact Ronald Hawley concerning training access options and applicable fees. As of 5/12/2017, the fee-based training option provides subtitles for all training videos in Arabic, Bulgarian, Chinese (Simplified & Traditional), Dutch, English, English UK, French, German, Hebrew, Italian, Japanese, Korean, Polish, Portuguese (Brazil), Portuguese (Portugal), Russian, Spanish (International), Spanish (Latin America), Croatian, Danish, Hungarian, Turkish, Lithuanian, Finnish, Czech and Swedish. This option also provides access, if needed, to an expert at the Knight ADRC should concerns or questions arise during training. Additionally, technical support is provided.

If you are part of a contracted study, pick from the available studies below to begin your training. You may need to contact your study coordinator for the password to access the study's application.



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Streaming Requirements


Click HERE to view our streaming requirements page.

Obtaining Technical Support

ALL technical support for training is provided via email (Mon-Fri, 8am-4pm Central Time, excluding holidays). If you need assistance, email [email protected]

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Lost your place in training?

If you failed to bookmark (also referred to as Add to Favorites) the module you are on when you stopped training, or had a computer glitch that has prevented you from picking up where you left off, you can visit THIS PAGE to request the correct link to resume your training.

How to bookmark web pages:

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    • For situations that deviate from the instructions provided at the link above, consult your IT support.

    Streaming or video playback problems?

    Multiple issues can affect your ability to stream videos. Consult our Streaming Requirements page for more information.